A clamping-closure system securely seals the Nalgene™ sanitary carboy, requiring no torque while eliminating back-off issues. To seal the closure, use a combination of gasket, end cap and sealing clamp. Silicone sanitary gaskets offers a reliable leakproof seal when used with Nalgene end caps and true union clamps. True union clamps offer reliable, repeatable seals when used in combination with silicone gasket and end caps.